| Reaction Details |
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 | Report a problem with these data |
| Target | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
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| Ligand | BDBM50086351 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1476003 (CHEMBL3428359) |
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| IC50 | 28±n/a nM |
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| Citation |  Haffner, CD; Becherer, JD; Boros, EE; Cadilla, R; Carpenter, T; Cowan, D; Deaton, DN; Guo, Y; Harrington, W; Henke, BR; Jeune, MR; Kaldor, I; Milliken, N; Petrov, KG; Preugschat, F; Schulte, C; Shearer, BG; Shearer, T; Smalley, TL; Stewart, EL; Stuart, JD; Ulrich, JC Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors. J Med Chem58:3548-71 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
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| Name: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
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| Synonyms: | CD38 | CD38_HUMAN | Lymphocyte differentiation antigen CD38 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34333.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1509931 |
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| Residue: | 300 |
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| Sequence: | MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFP
ETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCN
KILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDC
SNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEA
WVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
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| BDBM50086351 |
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| n/a |
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| Name | BDBM50086351 |
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| Synonyms: | CHEMBL3426057 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H12ClFN4OS |
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| Mol. Mass. | 386.83 |
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| SMILES | Cc1cc(cc2c(Nc3ccc(F)c(Cl)c3)nc(O)nc12)-c1cncs1 |
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| Structure | 
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