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TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
LigandBDBM50086322
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1476003 (CHEMBL3428359)
IC50 49±n/a nM
Citation Haffner, CDBecherer, JDBoros, EECadilla, RCarpenter, TCowan, DDeaton, DNGuo, YHarrington, WHenke, BRJeune, MRKaldor, IMilliken, NPetrov, KGPreugschat, FSchulte, CShearer, BGShearer, TSmalley, TLStewart, ELStuart, JDUlrich, JC Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors. J Med Chem58:3548-71 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Name:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Synonyms:CD38 | CD38_HUMAN | Lymphocyte differentiation antigen CD38
Type:PROTEIN
Mol. Mass.:34333.62
Organism:Homo sapiens (Human)
Description:ChEMBL_1509931
Residue:300
Sequence:
MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFP
ETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCN
KILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDC
SNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEA
WVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
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  Blast E-value cutoff:
BDBM50086322
n/a
NameBDBM50086322
Synonyms:CHEMBL3426188
TypeSmall organic molecule
Emp. Form.C18H20N4S
Mol. Mass.324.443
SMILESC[C@@H]1CCCC[C@@H]1Nc1ncnc2ccc(cc12)-c1cncs1 |r|
Structure
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