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TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
LigandBDBM50086406
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1476003 (CHEMBL3428359)
IC50 560±n/a nM
Citation Haffner, CDBecherer, JDBoros, EECadilla, RCarpenter, TCowan, DDeaton, DNGuo, YHarrington, WHenke, BRJeune, MRKaldor, IMilliken, NPetrov, KGPreugschat, FSchulte, CShearer, BGShearer, TSmalley, TLStewart, ELStuart, JDUlrich, JC Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors. J Med Chem58:3548-71 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Name:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Synonyms:CD38 | CD38_HUMAN | Lymphocyte differentiation antigen CD38
Type:PROTEIN
Mol. Mass.:34333.62
Organism:Homo sapiens (Human)
Description:ChEMBL_1509931
Residue:300
Sequence:
MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFP
ETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCN
KILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDC
SNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEA
WVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
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  Blast E-value cutoff:
BDBM50086406
n/a
NameBDBM50086406
Synonyms:CHEMBL3426084
TypeSmall organic molecule
Emp. Form.C18H13N5OS
Mol. Mass.347.394
SMILESNC(=O)c1ccc(Nc2ncnc3ccc(cc23)-c2cncs2)cc1
Structure
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