Ki Summary

Reaction Details

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Target

Lymphocyte differentiation antigen CD38

Ligand

BDBM50086433

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1476005

0.300000±n/a nM

Citation

Haffner CD; Becherer JD; Boros EE; Cadilla R; Carpenter T; Cowan D; Deaton DN; Guo Y; Harrington W; Henke BR; Jeune MR; Kaldor I; Milliken N; Petrov KG; Preugschat F; Schulte C; Shearer BG; Shearer T; Smalley TL; Stewart EL; Stuart JD; Ulrich JC Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors. J Med Chem 58:3548-71 (2015) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Lymphocyte differentiation antigen CD38

Name:

Lymphocyte differentiation antigen CD38

Synonyms:

n/a

Type:

PROTEIN

Mol. Mass.:

34333.62

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1509931

Residue:

300

Sequence:

MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFP
ETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCN
KILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDC
SNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEA
WVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI

BDBM50086433

n/a

Name

BDBM50086433

Synonyms:

CHEMBL3426034

Type

Small organic molecule

Emp. Form.

C22H27N3O3S

Mol. Mass.

413.533

SMILES

COCCO[C@H]1CC[C@@H](CC1)Nc1cc(=O)n(C)c2ccc(cc12)-c1cncs1 |r,wU:5.4,wD:8.11,(9.09,10.61,;8.02,10,;8.02,8.46,;6.68,7.69,;6.68,6.15,;5.34,5.38,;5.34,3.84,;4,3.07,;2.67,3.85,;2.68,5.39,;4.01,6.15,;1.33,3.08,;1.33,1.54,;2.66,.77,;2.66,-.77,;3.73,-1.38,;1.33,-1.54,;1.33,-2.77,;,-.77,;-1.33,-1.54,;-2.68,-.77,;-2.68,.77,;-1.33,1.54,;,.77,;-4.01,1.54,;-5.4,.91,;-6.43,2.07,;-5.65,3.39,;-4.14,3.06,)|

Structure