| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase ITK/TSK |
|---|
| Ligand | BDBM50086659 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1477113 (CHEMBL3428280) |
|---|
| Ki | 0.300000±n/a nM |
|---|
| Citation |  Burch, JD; Barrett, K; Chen, Y; DeVoss, J; Eigenbrot, C; Goldsmith, R; Ismaili, MH; Lau, K; Lin, Z; Ortwine, DF; Zarrin, AA; McEwan, PA; Barker, JJ; Ellebrandt, C; Kordt, D; Stein, DB; Wang, X; Chen, Y; Hu, B; Xu, X; Yuen, PW; Zhang, Y; Pei, Z Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo. J Med Chem58:3806-16 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase ITK/TSK |
|---|
| Name: | Tyrosine-protein kinase ITK/TSK |
|---|
| Synonyms: | EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 71839.20 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q08881 |
|---|
| Residue: | 620 |
|---|
| Sequence: | MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
|
|
|
|---|
| BDBM50086659 |
|---|
| n/a |
|---|
| Name | BDBM50086659 |
|---|
| Synonyms: | CHEMBL3426303 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H31N5O3S |
|---|
| Mol. Mass. | 481.61 |
|---|
| SMILES | CC1(C)CCc2c(C1)[nH]nc2C(=O)Nc1cnn(c1)[C@@H](C1CCCCS1(=O)=O)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
