| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
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| Ligand | BDBM50086692 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1477330 (CHEMBL3429296) |
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| Ki | 770±n/a nM |
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| Citation |  Burke, JP; Bian, Z; Shaw, S; Zhao, B; Goodwin, CM; Belmar, J; Browning, CF; Vigil, D; Friberg, A; Camper, DV; Rossanese, OW; Lee, T; Olejniczak, ET; Fesik, SW Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design. J Med Chem58:3794-805 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptosis regulator Bcl-2 |
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| Name: | Apoptosis regulator Bcl-2 |
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| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
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| Type: | Homodimer or heterodimer |
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| Mol. Mass.: | 26269.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10415 |
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| Residue: | 239 |
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| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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| BDBM50086692 |
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| n/a |
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| Name | BDBM50086692 |
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| Synonyms: | CHEMBL3426333 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23Cl2NO3 |
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| Mol. Mass. | 432.34 |
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| SMILES | Cc1cc(OCCCc2c(C(O)=O)n3CCCc4c(Cl)ccc2c34)cc(C)c1Cl |
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| Structure | 
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