| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
|---|
| Ligand | BDBM50087051 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1477829 (CHEMBL3428964) |
|---|
| Ki | 2.4±n/a nM |
|---|
| Citation |  Grandane, A; Tanc, M; Di Cesare Mannelli, L; Carta, F; Ghelardini, C; ?alubovskis, R; Supuran, CT 6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells. J Med Chem58:3975-83 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 12 |
|---|
| Name: | Carbonic anhydrase 12 |
|---|
| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 39456.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Catalytic domain of human cloned isozyme was used in the assay |
|---|
| Residue: | 354 |
|---|
| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
|
|
|
|---|
| BDBM50087051 |
|---|
| n/a |
|---|
| Name | BDBM50087051 |
|---|
| Synonyms: | CHEMBL3426533 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H13NO4S |
|---|
| Mol. Mass. | 315.344 |
|---|
| SMILES | Cc1ccc(cc1)C(=O)Nc1ccc2OS(=O)(=O)C=Cc2c1 |c:19| |
|---|
| Structure | 
|
|---|
Search and Browse
