| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
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| Ligand | BDBM50087047 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1477829 (CHEMBL3428964) |
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| Ki | 6.1±n/a nM |
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| Citation |  Grandane, A; Tanc, M; Di Cesare Mannelli, L; Carta, F; Ghelardini, C; ?alubovskis, R; Supuran, CT 6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells. J Med Chem58:3975-83 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 12 |
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| Name: | Carbonic anhydrase 12 |
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| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39456.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Catalytic domain of human cloned isozyme was used in the assay |
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| Residue: | 354 |
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| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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| BDBM50087047 |
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| n/a |
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| Name | BDBM50087047 |
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| Synonyms: | CHEMBL3426537 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H9NO4S2 |
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| Mol. Mass. | 307.345 |
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| SMILES | O=C(Nc1ccc2OS(=O)(=O)C=Cc2c1)c1cccs1 |c:11| |
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| Structure | 
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