| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Heat shock protein 75 kDa, mitochondrial |
|---|
| Ligand | BDBM50087524 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1478164 (CHEMBL3427925) |
|---|
| IC50 | 7230±n/a nM |
|---|
| Citation |  Patel, HJ; Patel, PD; Ochiana, SO; Yan, P; Sun, W; Patel, MR; Shah, SK; Tramentozzi, E; Brooks, J; Bolaender, A; Shrestha, L; Stephani, R; Finotti, P; Leifer, C; Li, Z; Gewirth, DT; Taldone, T; Chiosis, G Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. J Med Chem58:3922-43 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Heat shock protein 75 kDa, mitochondrial |
|---|
| Name: | Heat shock protein 75 kDa, mitochondrial |
|---|
| Synonyms: | HSP75 | TRAP1 | TRAP1_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 80120.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1478164 |
|---|
| Residue: | 704 |
|---|
| Sequence: | MARELRALLLWGRRLRPLLRAPALAAVPGGKPILCPRRTTAQLGPRRNPAWSLQAGRLFS
TQTAEDKEEPLHSIISSTESVQGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNA
SDALEKLRHKLVSDGQALPEMEIHLQTNAEKGTITIQDTGIGMTQEELVSNLGTIARSGS
KAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGVFE
IAEASGVRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNFVSFPLYLNGRRMNTLQAIWM
MDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDVSRELG
SSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQ
RLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYESSALPSGQL
TSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDTEVLFCFEQFDELTLLHLR
EFDKKKLISVETDIVVDHYKEEKFEDRSPAAECLSEKETEELMAWMRNVLGSRVTNVKVT
LRLDTHPAMVTVLEMGAARHFLRMQQLAKTQEERAQLLQPTLEINPRHALIKKLNQLRAS
EPGLAQLLVDQIYENAMIAAGLVDDPRAMVGRLNELLVKALERH
|
|
|
|---|
| BDBM50087524 |
|---|
| n/a |
|---|
| Name | BDBM50087524 |
|---|
| Synonyms: | CHEMBL3426756 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H11Cl2N5S |
|---|
| Mol. Mass. | 364.252 |
|---|
| SMILES | Nc1ncnc2n(CCC#C)c(Sc3ccc(Cl)cc3Cl)nc12 |
|---|
| Structure | 
|
|---|
Search and Browse
