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TargetTyrosine-protein phosphatase non-receptor type 1
LigandBDBM50087869
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1476208 (CHEMBL3429394)
Ki 17300±n/a nM
Citation Wagner, S; Schütz, A; Rademann, J Light-switched inhibitors of protein tyrosine phosphatase PTP1B based on phosphonocarbonyl phenylalanine as photoactive phosphotyrosine mimetic. Bioorg Med Chem23:2839-47 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein phosphatase non-receptor type 1
Name:Tyrosine-protein phosphatase non-receptor type 1
Synonyms:PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:Protein phosphatase
Mol. Mass.:49963.76
Organism:Homo sapiens (Human)
Description:Human recombinant GST-fusion PTP1B (1-435).
Residue:435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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  Blast E-value cutoff:
BDBM50087869
n/a
NameBDBM50087869
Synonyms:CHEMBL3426914
TypeSmall organic molecule
Emp. Form.C34H44N7Na4O17P
Mol. Mass.945.6827
SMILES[Na+].[Na+].[Na+].[Na+].CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(cc1)C(=O)P(O)([O-])=O)NC(=O)[C@H](CCC([O-])=O)NC(=O)[C@H](CC([O-])=O)NC(=O)[C@H](C)NC(=O)[C@H](CC([O-])=O)NC(C)=O)C(N)=O |r|
Structure
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