Reaction Details |
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Target | NAD-dependent protein deacetylase sirtuin-1 |
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Ligand | BDBM50178769 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1476843 (CHEMBL3429766) |
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IC50 | 500±n/a nM |
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Citation | Therrien, E; Larouche, G; Nguyen, N; Rahil, J; Lemieux, AM; Li, Z; Fournel, M; Yan, TP; Landry, AJ; Lefebvre, S; Wang, JJ; MacBeth, K; Heise, C; Nguyen, A; Besterman, JM; Déziel, R; Wahhab, A Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors. Bioorg Med Chem Lett25:2514-8 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NAD-dependent protein deacetylase sirtuin-1 |
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Name: | NAD-dependent protein deacetylase sirtuin-1 |
Synonyms: | NAD-Dependent Deacetylase Sirtuin-1 | NAD-dependent deacetylase sirtuin 1 | NAD-dependent protein deacetylase sirtuin-1 (SIRT1) | SIR1_HUMAN | SIR2-like protein 1 | SIR2L1 | SIRT1 | Sirtuin 1 (SIRT1) | Sirtuin-1 (SIRT1) | hSIR2 |
Type: | Developmental protein; hydrolase |
Mol. Mass.: | 81626.66 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 747 |
Sequence: | MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV
PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL
YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP
RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI
NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE
YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII
QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE
QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG
DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS
PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL
KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD
SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD
GDDQEAINEAISVKQEVTDMNYPSNKS
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BDBM50178769 |
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n/a |
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Name | BDBM50178769 |
Synonyms: | (+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CHEMBL420311 |
Type | Small organic molecule |
Emp. Form. | C13H13ClN2O |
Mol. Mass. | 248.708 |
SMILES | NC(=O)C1CCCc2c1[nH]c1ccc(Cl)cc21 |
Structure |
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