Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetNAD-dependent protein deacetylase sirtuin-1
LigandBDBM50178769
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1476843 (CHEMBL3429766)
IC50 500±n/a nM
Citation Therrien, ELarouche, GNguyen, NRahil, JLemieux, AMLi, ZFournel, MYan, TPLandry, AJLefebvre, SWang, JJMacBeth, KHeise, CNguyen, ABesterman, JMDéziel, RWahhab, A Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors. Bioorg Med Chem Lett25:2514-8 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
NAD-dependent protein deacetylase sirtuin-1
Name:NAD-dependent protein deacetylase sirtuin-1
Synonyms:NAD-Dependent Deacetylase Sirtuin-1 | NAD-dependent deacetylase sirtuin 1 | NAD-dependent protein deacetylase sirtuin-1 (SIRT1) | SIR1_HUMAN | SIR2-like protein 1 | SIR2L1 | SIRT1 | Sirtuin 1 (SIRT1) | Sirtuin-1 (SIRT1) | hSIR2
Type:Developmental protein; hydrolase
Mol. Mass.:81626.66
Organism:Homo sapiens (Human)
Description:n/a
Residue:747
Sequence:
MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV
PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL
YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP
RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI
NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE
YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII
QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE
QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG
DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS
PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL
KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD
SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD
GDDQEAINEAISVKQEVTDMNYPSNKS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50178769
n/a
NameBDBM50178769
Synonyms:(+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CHEMBL420311
TypeSmall organic molecule
Emp. Form.C13H13ClN2O
Mol. Mass.248.708
SMILESNC(=O)C1CCCc2c1[nH]c1ccc(Cl)cc21
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: