| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Voltage-dependent L-type calcium channel subunit alpha-1C |
|---|
| Ligand | BDBM50003655 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1478714 (CHEMBL3430615) |
|---|
| IC50 | 103000±n/a nM |
|---|
| Citation |  Mirams, GR; Cui, Y; Sher, A; Fink, M; Cooper, J; Heath, BM; McMahon, NC; Gavaghan, DJ; Noble, D Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovasc Res91:53-61 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Voltage-dependent L-type calcium channel subunit alpha-1C |
|---|
| Name: | Voltage-dependent L-type calcium channel subunit alpha-1C |
|---|
| Synonyms: | CAC1C_CAVPO | CACH2 | CACH2 | CACN2 | CACNA1C | CACNL1A1 | CCHL1A1 | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | Voltage-dependent L-type calcium channel subunit alpha-1C | Voltage-gated calcium channel subunit alpha Cav1.2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 19518.62 |
|---|
| Organism: | Cavia porcellus |
|---|
| Description: | ChEMBL_106600 |
|---|
| Residue: | 169 |
|---|
| Sequence: | FQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPISITFFRLFRVMRLVKLLSRGEGI
RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAV
LLLFRCATGEAWQDIMLACMPGKKRAPESEPSNSTEGETPCGSSFAVFY
|
|
|
|---|
| BDBM50003655 |
|---|
| n/a |
|---|
| Name | BDBM50003655 |
|---|
| Synonyms: | Phenytoin |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H12N2O2 |
|---|
| Mol. Mass. | 252.268 |
|---|
| SMILES | O=C1NC(=O)C(N1)(c1ccccc1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
