| Reaction Details |
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 | Report a problem with these data |
| Target | Voltage-dependent L-type calcium channel subunit alpha-1C |
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| Ligand | BDBM50017376 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1478723 (CHEMBL3430624) |
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| IC50 | 375±n/a nM |
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| Citation |  Mirams, GR; Cui, Y; Sher, A; Fink, M; Cooper, J; Heath, BM; McMahon, NC; Gavaghan, DJ; Noble, D Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovasc Res91:53-61 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Voltage-dependent L-type calcium channel subunit alpha-1C |
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| Name: | Voltage-dependent L-type calcium channel subunit alpha-1C |
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| Synonyms: | CAC1C_CAVPO | CACH2 | CACH2 | CACN2 | CACNA1C | CACNL1A1 | CCHL1A1 | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | Voltage-dependent L-type calcium channel subunit alpha-1C | Voltage-gated calcium channel subunit alpha Cav1.2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 19518.62 |
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| Organism: | Cavia porcellus |
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| Description: | ChEMBL_106600 |
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| Residue: | 169 |
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| Sequence: | FQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPISITFFRLFRVMRLVKLLSRGEGI
RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAV
LLLFRCATGEAWQDIMLACMPGKKRAPESEPSNSTEGETPCGSSFAVFY
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| BDBM50017376 |
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| n/a |
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| Name | BDBM50017376 |
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| Synonyms: | (+/-)1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-ol | 1-(4-tert-Butyl-phenyl)-4-[4-(hydroxy-diphenyl-methyl)-piperidin-1-yl]-butan-1-ol | 1-(4-tert-Butyl-phenyl)-4-[4-(hydroxy-diphenyl-methyl)-piperidin-1-yl]-butan-1-ol(Terfenadine) | 1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-ol | CHEMBL17157 | TERFENADINE | teraenadine |
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| Type | Small organic molecule |
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| Emp. Form. | C32H41NO2 |
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| Mol. Mass. | 471.6734 |
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| SMILES | CC(C)(C)c1ccc(cc1)C(O)CCCN1CCC(CC1)C(O)(c1ccccc1)c1ccccc1 |
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| Structure | 
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