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TargetVoltage-gated potassium channel subunit Kv4.3
LigandBDBM50165008
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1478665
IC50 12589±n/a nM
Citation Mirams GRDavies MRBrough SJBridgland-Taylor MHCui YGavaghan DJAbi-Gerges N Prediction of Thorough QT study results using action potential simulations based on ion channel screens. J Pharmacol Toxicol Methods 70:246-54 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Voltage-gated potassium channel subunit Kv4.3
Name:Voltage-gated potassium channel
Synonyms:Potassium voltage-gated channel subfamily D member 3 | Voltage-gated potassium channel subunit Kv4.3
Type:PROTEIN
Mol. Mass.:73464.62
Organism:Homo sapiens (Human)
Description:ChEMBL_1478652
Residue:655
Sequence:
MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLER
YPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAF
YGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTST
LALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVE
YLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKF
SRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWY
TIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRR
AQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLL
HCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHP
GLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDG
LRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSIASNVVKVSAL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50165008
n/a
NameBDBM50165008
Synonyms:(+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl)-p-cresol | (+)-Tolterodine | 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol | CHEMBL1382 | TOLTERODINE
TypeSmall organic molecule
Emp. Form.C22H31NO
Mol. Mass.325.4876
SMILESCC(C)N(CC[C@H](c1ccccc1)c1cc(C)ccc1O)C(C)C
Structure
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