| Reaction Details |
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 | Report a problem with these data |
| Target | Voltage-dependent L-type calcium channel subunit alpha-1C |
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| Ligand | BDBM50341448 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1479067 (CHEMBL3436225) |
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| IC50 | 20200±n/a nM |
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| Citation |  Wisniowska, B; Mendyk, A; Fijorek, K; Glinka, A; Polak, S Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. J Appl Toxicol32:858-66 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Voltage-dependent L-type calcium channel subunit alpha-1C |
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| Name: | Voltage-dependent L-type calcium channel subunit alpha-1C |
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| Synonyms: | CAC1C_CAVPO | CACH2 | CACH2 | CACN2 | CACNA1C | CACNL1A1 | CCHL1A1 | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | Voltage-dependent L-type calcium channel subunit alpha-1C | Voltage-gated calcium channel subunit alpha Cav1.2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 19518.62 |
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| Organism: | Cavia porcellus |
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| Description: | ChEMBL_106600 |
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| Residue: | 169 |
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| Sequence: | FQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPISITFFRLFRVMRLVKLLSRGEGI
RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAV
LLLFRCATGEAWQDIMLACMPGKKRAPESEPSNSTEGETPCGSSFAVFY
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| BDBM50341448 |
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| n/a |
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| Name | BDBM50341448 |
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| Synonyms: | 4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-phthalazin-1-one | AZELASTINE | Astelin | Astepro | CHEMBL639 | Optilast | Optivar | Rhinolast | US20230414632, Compound II-a | rac-Azelastine |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24ClN3O |
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| Mol. Mass. | 381.898 |
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| SMILES | CN1CCCC(CC1)n1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O |
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| Structure | 
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