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TargetVoltage-dependent L-type calcium channel subunit alpha-1C
LigandBDBM81939
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1479175
IC50 164±n/a nM
Citation Wisniowska BMendyk AFijorek KGlinka APolak S Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. J Appl Toxicol 32:858-66 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Voltage-dependent L-type calcium channel subunit alpha-1C
Name:Voltage-dependent L-type calcium channel subunit alpha-1C
Synonyms:CACH2 | CACN2 | CACNA1C | CACNL1A1 | CCHL1A1 | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | Voltage-dependent L-type calcium channel subunit alpha-1C | Voltage-gated calcium channel subunit alpha Cav1.2
Type:PROTEIN
Mol. Mass.:19518.62
Organism:Cavia porcellus
Description:ChEMBL_106600
Residue:169
Sequence:
FQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPISITFFRLFRVMRLVKLLSRGEGI
RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAV
LLLFRCATGEAWQDIMLACMPGKKRAPESEPSNSTEGETPCGSSFAVFY
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BDBM81939
n/a
NameBDBM81939
Synonyms:CAS_52-53-9 | NSC_62969 | VERAPAMIL
TypeSmall organic molecule
Emp. Form.C27H38N2O4
Mol. Mass.454.6016
SMILESCOc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
Structure
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