Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetVoltage-dependent L-type calcium channel subunit alpha-1C
LigandBDBM50002338
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1479168 (CHEMBL3436144)
IC50 1300±n/a nM
Citation Wisniowska, B; Mendyk, A; Fijorek, K; Glinka, A; Polak, S Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. J Appl Toxicol32:858-66 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Voltage-dependent L-type calcium channel subunit alpha-1C
Name:Voltage-dependent L-type calcium channel subunit alpha-1C
Synonyms:CAC1C_CAVPO | CACH2 | CACH2 | CACN2 | CACNA1C | CACNL1A1 | CCHL1A1 | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | Voltage-dependent L-type calcium channel subunit alpha-1C | Voltage-gated calcium channel subunit alpha Cav1.2
Type:PROTEIN
Mol. Mass.:19518.62
Organism:Cavia porcellus
Description:ChEMBL_106600
Residue:169
Sequence:
FQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPISITFFRLFRVMRLVKLLSRGEGI
RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAV
LLLFRCATGEAWQDIMLACMPGKKRAPESEPSNSTEGETPCGSSFAVFY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50002338
n/a
NameBDBM50002338
Synonyms:(Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine | 10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine | 10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine | 10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine (thioridazine) | CHEMBL479 | MELLARIL | MELLARIL-S | THIORIDAZINE | TP-21 | US9504692, Thioridazine
TypeSmall organic molecule
Emp. Form.C21H26N2S2
Mol. Mass.370.575
SMILESCSc1ccc2Sc3ccccc3N(CCC3CCCCN3C)c2c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: