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TargetVoltage-dependent L-type calcium channel subunit alpha-1C
LigandBDBM50101817
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1479130
IC50 300±n/a nM
Citation Wisniowska BMendyk AFijorek KGlinka APolak S Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. J Appl Toxicol 32:858-66 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Voltage-dependent L-type calcium channel subunit alpha-1C
Name:Voltage-dependent L-type calcium channel subunit alpha-1C
Synonyms:CACH2 | CACN2 | CACNA1C | CACNL1A1 | CCHL1A1 | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | Voltage-dependent L-type calcium channel subunit alpha-1C | Voltage-gated calcium channel subunit alpha Cav1.2
Type:PROTEIN
Mol. Mass.:19518.62
Organism:Cavia porcellus
Description:ChEMBL_106600
Residue:169
Sequence:
FQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPISITFFRLFRVMRLVKLLSRGEGI
RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAV
LLLFRCATGEAWQDIMLACMPGKKRAPESEPSNSTEGETPCGSSFAVFY
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  Blast E-value cutoff:
BDBM50101817
n/a
NameBDBM50101817
Synonyms:Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CHEBI:7565 | NIFEDIPINE | Nifedipine | Procardia | Procardia Xl
TypeSmall organic molecule
Emp. Form.C17H18N2O6
Mol. Mass.346.3346
SMILESCOC(=O)C1=C(C)NC(C)=C(C1c1ccccc1[N+]([O-])=O)C(=O)OC |c:4,9|
Structure
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