| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Voltage-dependent L-type calcium channel subunit alpha-1C |
|---|
| Ligand | BDBM50101970 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1479101 (CHEMBL3436077) |
|---|
| IC50 | 26±n/a nM |
|---|
| Citation |  Wisniowska, B; Mendyk, A; Fijorek, K; Glinka, A; Polak, S Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. J Appl Toxicol32:858-66 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Voltage-dependent L-type calcium channel subunit alpha-1C |
|---|
| Name: | Voltage-dependent L-type calcium channel subunit alpha-1C |
|---|
| Synonyms: | CAC1C_CAVPO | CACH2 | CACH2 | CACN2 | CACNA1C | CACNL1A1 | CCHL1A1 | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | Voltage-dependent L-type calcium channel subunit alpha-1C | Voltage-gated calcium channel subunit alpha Cav1.2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 19518.62 |
|---|
| Organism: | Cavia porcellus |
|---|
| Description: | ChEMBL_106600 |
|---|
| Residue: | 169 |
|---|
| Sequence: | FQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPISITFFRLFRVMRLVKLLSRGEGI
RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAV
LLLFRCATGEAWQDIMLACMPGKKRAPESEPSNSTEGETPCGSSFAVFY
|
|
|
|---|
| BDBM50101970 |
|---|
| n/a |
|---|
| Name | BDBM50101970 |
|---|
| Synonyms: | CHEMBL463726 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H36N2O6S |
|---|
| Mol. Mass. | 564.692 |
|---|
| SMILES | COc1ccc(cc1)[C@@H]1Sc2ccccc2N(CCN(C)CCc2ccc(OC)c(OC)c2)C(=O)[C@@H]1OC(C)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
