Reaction Details | |||
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Target | Voltage-dependent L-type calcium channel subunit alpha-1C | ||
Ligand | BDBM50101964 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1479138 (CHEMBL3436114) | ||
IC50 | 170±n/a nM | ||
Citation | Wisniowska, B; Mendyk, A; Fijorek, K; Glinka, A; Polak, S Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. J Appl Toxicol32:858-66 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Voltage-dependent L-type calcium channel subunit alpha-1C | |||
Name: | Voltage-dependent L-type calcium channel subunit alpha-1C | ||
Synonyms: | CAC1C_RAT | Cach2 | Cacn2 | Cacna1c | Cacnl1a1 | Calcium channel | Calcium channel (Type L) | Calcium channel diltiazem | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | Cchl1a1 | RBC | Rat brain class C | Voltage-dependent L-type calcium channel subunit alpha-1C | Voltage-gated L-type calcium channel | Voltage-gated L-type calcium channel alpha-1C subunit | Voltage-gated calcium channel subunit alpha Cav1.2 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 243492.26 | ||
Organism: | RAT | ||
Description: | Calcium channel 0 RAT::P22002 | ||
Residue: | 2169 | ||
Sequence: |
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BDBM50101964 | |||
n/a | |||
Name | BDBM50101964 | ||
Synonyms: | CHEMBL3436047 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H32ClFINO2 | ||
Mol. Mass. | 559.883 | ||
SMILES | [I-].CCCC[N+]1(CCCC(=O)c2ccc(F)cc2)CCC(O)(CC1)c1ccc(Cl)cc1 |(13.62,,;-.15,5.21,;-.68,3.76,;.31,2.58,;-.22,1.14,;.77,-.04,;-.56,-.81,;-1.89,-.04,;-3.23,-.81,;-4.56,-.04,;-4.56,1.5,;-5.9,-.81,;-5.9,-2.35,;-7.23,-3.12,;-8.56,-2.35,;-9.9,-3.12,;-8.56,-.81,;-7.23,-.04,;1.76,1.14,;3.28,.87,;3.81,-.58,;5.02,-1.53,;2.82,-1.76,;1.3,-1.49,;5.27,-.1,;5.59,1.4,;7.06,1.88,;8.2,.85,;9.66,1.32,;7.88,-.66,;6.41,-1.13,)| | ||
Structure |