| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-glucuronosyltransferase 1A8 |
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| Ligand | BDBM50358252 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1486245 (CHEMBL3534364) |
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| Ki | 354000±n/a nM |
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| Citation |  Shiraga, T; Yajima, K; Suzuki, K; Suzuki, K; Hashimoto, T; Iwatsubo, T; Miyashita, A; Usui, T Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine. Drug Metab Dispos40:276-82 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-glucuronosyltransferase 1A8 |
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| Name: | UDP-glucuronosyltransferase 1A8 |
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| Synonyms: | GNT1 | GNT1 | UD18_HUMAN | UDP-glucuronosyltransferase 1-8 | UDP-glucuronosyltransferase 1-H | UDP-glucuronosyltransferase 1A8 | UDPGT 1-8 | UGT-1H | UGT1 | UGT1*8 | UGT1-08 | UGT1.8 | UGT1A8 | UGT1H |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59751.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104086 |
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| Residue: | 530 |
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| Sequence: | MARTGWTSPIPLCVSLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLGKSLNCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLF
FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDACGLIVAKYFSLPSVVFARGIACHYLEEG
AQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLFCQYFSKNALEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
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| BDBM50358252 |
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| n/a |
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| Name | BDBM50358252 |
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| Synonyms: | CHEMBL1922235 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H30N4O4 |
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| Mol. Mass. | 474.5515 |
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| SMILES | COc1ccc(cc1)C(=O)Nc1cccc(O)c1NC(=O)c1ccc(cc1)N1CCCN(C)CC1 |
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| Structure | 
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