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TargetSolute carrier organic anion transporter family member 1B3 (OATP1B3)
LigandBDBM50088491
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1494638
IC50 5000±n/a nM
Citation Köck KXie YHawke RLOberlies NHBrouwer KL Interaction of silymarin flavonolignans with organic anion-transporting polypeptides. Drug Metab Dispos 41:958-65 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Solute carrier organic anion transporter family member 1B3 (OATP1B3)
Name:Solute carrier organic anion transporter family member 1B3 (OATP1B3)
Synonyms:Organic Anion Transporter OATP1B3 | Solute carrier organic anion transporter family member 1B3
Type:Protein
Mol. Mass.:77425.75
Organism:Homo sapiens (Human)
Description:Q9NPD5
Residue:702
Sequence:
MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKISITQIERRFD
ISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFFMGY
YRYSKETHINPSENSTSSLSTCLINQTLSFNGTSPEIVEKDCVKESGSHMWIYVFMGNML
RGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYV
DLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKNPNKPQKERKISLSLHVLK
TNDDRNQTANLTNQGKNVTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVF
KYMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFL
FQLLYFPLICESKSVAGLTLTYDGNNSVASHVDVPLSYCNSECNCDESQWEPVCGNNGIT
YLSPCLAGCKSSSGIKKHTVFYNCSCVEVTGLQNRNYSAHLGECPRDNTCTRKFFIYVAI
QVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCM
KWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPALVLYIVFIFAMKKKFQGKDTKASD
NERKVMDEANLEFLNNGEHFVPSAGTDSKTCNLDMQDNAAAN
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  Blast E-value cutoff:
BDBM50088491
n/a
NameBDBM50088491
Synonyms:SILYBIN B | Silybin B
TypeSmall organic molecule
Emp. Form.C25H22O10
Mol. Mass.482.4362
SMILESCOc1cc(ccc1O)[C@@H]1Oc2cc(ccc2O[C@H]1CO)[C@H]1Oc2cc(O)cc(O)c2C(=O)[C@@H]1O |r|
Structure
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