| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor subfamily 1 group I member 2 |
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| Ligand | BDBM50103612 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1487568 (CHEMBL3531874) |
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| EC50 | 12600±n/a nM |
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| Citation |  Shukla, SJ; Sakamuru, S; Huang, R; Moeller, TA; Shinn, P; Vanleer, D; Auld, DS; Austin, CP; Xia, M Identification of clinically used drugs that activate pregnane X receptors. Drug Metab Dispos39:151-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor subfamily 1 group I member 2 |
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| Name: | Nuclear receptor subfamily 1 group I member 2 |
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| Synonyms: | NR1I2_RAT | Nr1i2 | Nuclear receptor subfamily 1 group I member 2 | Orphan nuclear receptor PXR | Pregnane X receptor | Pxr |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49664.53 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_105143 |
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| Residue: | 431 |
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| Sequence: | MRPEERWNHVGLVQREEADSVLEEPINVDEEDGGLQICRVCGDKANGYHFNVMTCEGCKG
FFRRAMKRNVRLRCPFRKGTCEITRKTRRQCQACRLRKCLESGMKKEMIMSDAAVEQRRA
LIKRKKREKIEAPPPGGQGLTEEQQALIQELMDAQMQTFDTTFSHFKDFRLPAVFHSDCE
LPEVLQASLLEDPATWSQIMKDSVPMKISVQLRGEDGSIWNYQPPSKSDGKEIIPLLPHL
ADVSTYMFKGVINFAKVISHFRELPIEDQISLLKGATFEMCILRFNTMFDTETGTWECGR
LAYCFEDPNGGFQKLLLDPLMKFHCMLKKLQLREEEYVLMQAISLFSPDRPGVVQRSVVD
QLQERFALTLKAYIECSRPYPAHRFLFLKIMAVLTELRSINAQQTQQLLRIQDTHPFATP
LMQELFSSTDG
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| BDBM50103612 |
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| n/a |
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| Name | BDBM50103612 |
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| Synonyms: | CHEMBL2356116 |
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| Type | Small organic molecule |
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| Emp. Form. | C41H49ClN2O9 |
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| Mol. Mass. | 749.289 |
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| SMILES | Cl.COc1ccc(CCN(CCc2ccc(OC)c(OC)c2OC)C(=O)C(C2=NCCc3cc(OC)c(OC)cc23)c2ccccc2)c(OC)c1OC |t:27| |
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| Structure | 
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