| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 2B6 |
|---|
| Ligand | BDBM82507 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1489171 (CHEMBL3531984) |
|---|
| Ki | 10000±n/a nM |
|---|
| Citation |  Amunugama, HT; Zhang, H; Hollenberg, PF Mechanism-based inactivation of cytochrome P450 2B6 by methadone through destruction of prosthetic heme. Drug Metab Dispos40:1765-70 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 2B6 |
|---|
| Name: | Cytochrome P450 2B6 |
|---|
| Synonyms: | CP2B6_HUMAN | CYP2B6 | Cytochrome P450 2B6 (CYP2B6) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 56289.75 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P20813 |
|---|
| Residue: | 491 |
|---|
| Sequence: | MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE
KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR
WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC
SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE
INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT
ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS
DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL
KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI
PPTYQIRFLPR
|
|
|
|---|
| BDBM82507 |
|---|
| n/a |
|---|
| Name | BDBM82507 |
|---|
| Synonyms: | (+/-)-Methadone | CAS_5967-73-7 | METHADONE | Methadone-HCL,(-) | NSC_22266 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H27NO |
|---|
| Mol. Mass. | 309.4452 |
|---|
| SMILES | CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
