Reaction Details |
| Report a problem with these data |
Target | Cytochrome P450 3A5 |
---|
Ligand | BDBM5445 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1491569 (CHEMBL3535031) |
---|
Ki | 37600±n/a nM |
---|
Citation | Chan, EC; New, LS; Chua, TB; Yap, CW; Ho, HK; Nelson, SD Interaction of lapatinib with cytochrome P450 3A5. Drug Metab Dispos40:1414-22 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cytochrome P450 3A5 |
---|
Name: | Cytochrome P450 3A5 |
Synonyms: | CP3A5_HUMAN | CYP3A5 | Cytochrome P450 3A5 | Cytochrome P450 3A5 (CYP3A5) |
Type: | Protein |
Mol. Mass.: | 57118.00 |
Organism: | Homo sapiens (Human) |
Description: | P20815 |
Residue: | 502 |
Sequence: | MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF
DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL
AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS
MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL
FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI
IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV
NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS
KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG
LLQPEKPIVLKVDSRDGTLSGE
|
|
|
BDBM5445 |
---|
n/a |
---|
Name | BDBM5445 |
Synonyms: | CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapatinib | N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine | N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine | Tykerb | US10507209, Compound Lapatinib | US10822334, Compound Lapatinib | US9730934, Lapatinib ditosylate | cid_208908 |
Type | Small organic molecule |
Emp. Form. | C29H26ClFN4O4S |
Mol. Mass. | 581.058 |
SMILES | CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 |
Structure |
|