| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-glucuronosyltransferase 1A1 |
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| Ligand | BDBM50044561 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1493885 (CHEMBL3528266) |
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| Ki | 4670±n/a nM |
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| Citation |  Uchihashi, S; Fukumoto, H; Onoda, M; Hayakawa, H; Ikushiro, S; Sakaki, T Metabolism of the c-Fos/activator protein-1 inhibitor T-5224 by multiple human UDP-glucuronosyltransferase isoforms. Drug Metab Dispos39:803-13 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-glucuronosyltransferase 1A1 |
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| Name: | UDP-glucuronosyltransferase 1A1 |
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| Synonyms: | Bilirubin-specific UDPGT isozyme 1 | GNT1 | UD11_HUMAN | UDP-glucuronosyltransferase 1-1 | UDP-glucuronosyltransferase 1-A | UDP-glucuronosyltransferase 1A1 | UDPGT 1-1 | UGT-1A | UGT1 | UGT1*1 | UGT1-01 | UGT1.1 | UGT1A | UGT1A1 | Uridine-5'-diphosphoglucuronosyltransferase 1A1 | hUG-BR1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 59604.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22309 |
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| Residue: | 533 |
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| Sequence: | MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
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| BDBM50044561 |
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| n/a |
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| Name | BDBM50044561 |
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| Synonyms: | CHEMBL3222137 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H27NO8 |
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| Mol. Mass. | 517.5266 |
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| SMILES | OC(=O)CCc1cc(ccc1OCc1ccc2c(O)noc2c1)C(=O)c1ccc(OC2CCCC2)cc1O |
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| Structure | 
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