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TargetCytochrome P450 3A5
LigandBDBM50088503
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1486113 (CHEMBL3532902)
Ki 2000±n/a nM
Citation Walsky, RLObach, RSHyland, RKang, PZhou, SWest, MGeoghegan, KFHelal, CJWalker, GSGoosen, TCZientek, MA Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs. Drug Metab Dispos40:1686-97 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 3A5
Name:Cytochrome P450 3A5
Synonyms:CP3A5_HUMAN | CYP3A5 | Cytochrome P450 3A5 | Cytochrome P450 3A5 (CYP3A5)
Type:Protein
Mol. Mass.:57118.00
Organism:Homo sapiens (Human)
Description:P20815
Residue:502
Sequence:
MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF
DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL
AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS
MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL
FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI
IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV
NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS
KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG
LLQPEKPIVLKVDSRDGTLSGE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50088503
n/a
NameBDBM50088503
Synonyms:CHEMBL3527048
TypeSmall organic molecule
Emp. Form.C26H32N8
Mol. Mass.456.5859
SMILESCc1ccc(cc1)-c1c(cnn1C)-c1nn(C)c2ncnc(N3CC[C@@H](C3)N3CCCCC3)c12 |r|
Structure
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