| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-glucuronosyltransferase 1A1 |
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| Ligand | BDBM50301375 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1486476 (CHEMBL3531466) |
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| IC50 | 5600±n/a nM |
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| Citation |  Zhou, J; Tracy, TS; Remmel, RP Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors. Drug Metab Dispos39:322-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-glucuronosyltransferase 1A1 |
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| Name: | UDP-glucuronosyltransferase 1A1 |
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| Synonyms: | Bilirubin-specific UDPGT isozyme 1 | GNT1 | UD11_HUMAN | UDP-glucuronosyltransferase 1-1 | UDP-glucuronosyltransferase 1-A | UDP-glucuronosyltransferase 1A1 | UDPGT 1-1 | UGT-1A | UGT1 | UGT1*1 | UGT1-01 | UGT1.1 | UGT1A | UGT1A1 | Uridine-5'-diphosphoglucuronosyltransferase 1A1 | hUG-BR1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 59604.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22309 |
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| Residue: | 533 |
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| Sequence: | MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
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| BDBM50301375 |
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| n/a |
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| Name | BDBM50301375 |
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| Synonyms: | 3,3',5,5'-tetraiodo-L-thyronine | 3,5,3',5'-tetraiodo-L-thyronine | 4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine | CHEMBL1624 | L-T4 | L-thyroxine | O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine | levothyroxine |
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| Type | Small organic molecule |
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| Emp. Form. | C15H11I4NO4 |
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| Mol. Mass. | 776.87 |
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| SMILES | N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O |r| |
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| Structure | 
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