Ki Summary

Reaction Details

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Target

Sodium/nucleoside cotransporter 2

Ligand

BDBM50088517

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1494516 (CHEMBL3528993)

IC50

32000±n/a nM

Citation

Lepist, EI; Damaraju, VL; Zhang, J; Gati, WP; Yao, SY; Smith, KM; Karpinski, E; Young, JD; Leung, KH; Cass, CE Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1. Drug Metab Dispos41:916-22 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sodium/nucleoside cotransporter 2

Name:

Sodium/nucleoside cotransporter 2

Synonyms:

CNT2 | S28A2_HUMAN | SLC28A2

Type:

PROTEIN

Mol. Mass.:

71934.06

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1477251

Residue:

658

Sequence:

MEKASGRQSIALSTVETGTVNPGLELMEKEVEPEGSKRTDAQGHSLGDGLGPSTYQRRSR
WPFSKARSFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVH
SFLKKLLGKKLTRCLKPFENSRLRLWTKWVFAGVSLVGLILWLALDTAQRPEQLIPFAGI
CMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYT
VAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTA
TETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDAS
SLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLA
TNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMV
AEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLS
SIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGILYVPRGAEADCVSFPN
TSFTNRTYETYMCCRGLFQSTSLNGTNPPSFSGPWEDKEFSAMALTNCCGFYNNTVCA

BDBM50088517

n/a

Name

BDBM50088517

Synonyms:

CHEBI:16704 | Uridine

Type

Small organic molecule

Emp. Form.

C9H12N2O6

Mol. Mass.

244.2014

SMILES

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|

Structure