Reaction Details |
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Target | Kynurenine 3-monooxygenase |
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Ligand | BDBM50061916 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1487469 (CHEMBL3536664) |
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IC50 | 170±n/a nM |
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Citation | Beconi, MG; Yates, D; Lyons, K; Matthews, K; Clifton, S; Mead, T; Prime, M; Winkler, D; O'Connell, C; Walter, D; Toledo-Sherman, L; Munoz-Sanjuan, I; Dominguez, C Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048. Drug Metab Dispos40:2297-306 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Kynurenine 3-monooxygenase |
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Name: | Kynurenine 3-monooxygenase |
Synonyms: | KMO | KMO_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 55831.03 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1487479 |
Residue: | 486 |
Sequence: | MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSH
RGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLT
AAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKK
PRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMP
FEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCV
LLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLS
MYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKK
VINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQI
SNLISR
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BDBM50061916 |
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n/a |
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Name | BDBM50061916 |
Synonyms: | 3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benzenesulfonamide | CHEMBL134915 |
Type | Small organic molecule |
Emp. Form. | C17H15N3O6S2 |
Mol. Mass. | 421.448 |
SMILES | COc1ccc(cc1OC)S(=O)(=O)Nc1nc(cs1)-c1cccc(c1)[N+]([O-])=O |
Structure |
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