| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine 3-monooxygenase |
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| Ligand | BDBM50061916 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1487470 (CHEMBL3536665) |
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| IC50 | 12000±n/a nM |
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| Citation |  Beconi, MG; Yates, D; Lyons, K; Matthews, K; Clifton, S; Mead, T; Prime, M; Winkler, D; O'Connell, C; Walter, D; Toledo-Sherman, L; Munoz-Sanjuan, I; Dominguez, C Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048. Drug Metab Dispos40:2297-306 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine 3-monooxygenase |
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| Name: | Kynurenine 3-monooxygenase |
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| Synonyms: | KMO_MOUSE | Kmo | Kynurenine 3-hydroxylase | Kynurenine 3-monooxygenase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54550.12 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_109577 |
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| Residue: | 479 |
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| Sequence: | MASSDTQGKRVAVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVAKSARGRSINLALSY
RGRQALKAIGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISRENLNKDLLT
AVESYANAKVHFGHKLSKCIPEEGVLTVLGPDKVPRDVTCDLVVGCDGAYSTVRAHLMKK
PRFDYTQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAYMMIALPNMDKSFTCTLFMP
FEEFERLPTRSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSHCV
LMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNNLSMCLPEFSRFRIPDDHAISDLS
MYNYIEMRAHVNSRWFLFQKLLDKFLHAIMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKK
VINRGLFVLGSLIAIGGTYLLVHHLSLRPLEFLRRPAWMGTTGYWTRSTDISLQVPWSY
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| BDBM50061916 |
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| n/a |
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| Name | BDBM50061916 |
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| Synonyms: | 3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benzenesulfonamide | CHEMBL134915 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15N3O6S2 |
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| Mol. Mass. | 421.448 |
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| SMILES | COc1ccc(cc1OC)S(=O)(=O)Nc1nc(cs1)-c1cccc(c1)[N+]([O-])=O |
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| Structure | 
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