| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine 3-monooxygenase |
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| Ligand | BDBM50088520 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1487468 (CHEMBL3536663) |
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| IC50 | 7100±n/a nM |
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| Citation |  Beconi, MG; Yates, D; Lyons, K; Matthews, K; Clifton, S; Mead, T; Prime, M; Winkler, D; O'Connell, C; Walter, D; Toledo-Sherman, L; Munoz-Sanjuan, I; Dominguez, C Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048. Drug Metab Dispos40:2297-306 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine 3-monooxygenase |
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| Name: | Kynurenine 3-monooxygenase |
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| Synonyms: | KMO_RAT | Kmo |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54371.88 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1487468 |
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| Residue: | 478 |
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| Sequence: | MASSDTEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVANFMRGRSINLALSY
RGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLT
AVESYPNAKVHFGHKLSKCCPEEGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKK
PRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMS
FEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCV
LMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLS
MYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKK
VINRGLFVLGSLVAIGSAYILVHHLSPRPLELLRSAWTGTSGHWNRSADISPRVPWSH
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| BDBM50088520 |
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| n/a |
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| Name | BDBM50088520 |
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| Synonyms: | CHEMBL3526575 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26N4O6S2 |
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| Mol. Mass. | 518.606 |
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| SMILES | COc1ccc(cc1OC)S(=O)(=O)Nc1nc(c(CN2CCCCC2)s1)-c1cccc(c1)[N+]([O-])=O |
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| Structure | 
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