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TargetVoltage-gated potassium channel subunit Kv2.1 (Kv2.1)
LigandBDBM50088572
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1496410
IC50 1000±n/a nM
Citation Kim HYang IRyu SYWon DHGiri AGWang WChoi HChin JHahn DKim EHan CLee JNam SJHo WKKang H Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015. J Nat Prod 78:363-7 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Voltage-gated potassium channel subunit Kv2.1 (Kv2.1)
Name:Voltage-gated potassium channel subunit Kv2.1 (Kv2.1)
Synonyms:DRK1 | Delayed rectifier potassium channel 1 | KCNB1 | Potassium voltage-gated channel subfamily B member 1 | Voltage-gated potassium channel subunit Kv2.1 | h-DRK1
Type:Protein
Mol. Mass.:95890.66
Organism:Homo sapiens (Human)
Description:Q14721
Residue:858
Sequence:
MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKL
RDCNTHDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELD
YWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLE
KPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWF
TMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFR
IMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTK
FKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFY
KEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQD
NHLSPNKWKWTKRTLSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLEDMYNKMAKTQ
SQPILNTKESAAQSKPKEELEMESIPSPVAPLPTRTEGVIDMRSMSSIDSFISCATDFPE
ATRFSHSPLTSLPSKTGGSTAPEVGWRGALGASGGRFVEANPSPDASQHSSFFIESPKSS
MKTNNPLKLRALKVNFMEGDPSPLLPVLGMYHDPLRNRGSAAAAVAGLECATLLDKAVLS
PESSIYTTASAKTPPRSPEKHTAIAFNFEAGVHQYIDADTDDEGQLLYSVDSSPPKSLPG
STSPKFSTGTRSEKNHFESSPLPTSPKFLRQNCIYSTEALTGKGPSGQEKCKLENHISPD
VRVLPGGGAHGSTRDQSI
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  Blast E-value cutoff:
BDBM50088572
n/a
NameBDBM50088572
Synonyms:CHEMBL3577209
TypeSmall organic molecule
Emp. Form.C36H36O11
Mol. Mass.644.6644
SMILESCOc1cccc(OC)c1C(=O)c1c(O)cc(C)c(OC)c1CC(=O)c1c(OC)c(C)cc(O)c1C(=O)c1c(OC)cccc1OC
Structure
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