| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily B member 1 |
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| Ligand | BDBM50088573 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1496410 (CHEMBL3580176) |
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| IC50 | 590±n/a nM |
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| Citation |  Kim, H; Yang, I; Ryu, SY; Won, DH; Giri, AG; Wang, W; Choi, H; Chin, J; Hahn, D; Kim, E; Han, C; Lee, J; Nam, SJ; Ho, WK; Kang, H Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015. J Nat Prod78:363-7 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily B member 1 |
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| Name: | Potassium voltage-gated channel subfamily B member 1 |
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| Synonyms: | DRK1 | Delayed rectifier potassium channel 1 | KCNB1 | KCNB1_HUMAN | Potassium voltage-gated channel subfamily B member 1 | Voltage-gated potassium channel subunit Kv2.1 | Voltage-gated potassium channel subunit Kv2.1 (Kv2.1) | h-DRK1 |
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| Type: | Protein |
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| Mol. Mass.: | 95890.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14721 |
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| Residue: | 858 |
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| Sequence: | MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKL
RDCNTHDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELD
YWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLE
KPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWF
TMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFR
IMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTK
FKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFY
KEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQD
NHLSPNKWKWTKRTLSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLEDMYNKMAKTQ
SQPILNTKESAAQSKPKEELEMESIPSPVAPLPTRTEGVIDMRSMSSIDSFISCATDFPE
ATRFSHSPLTSLPSKTGGSTAPEVGWRGALGASGGRFVEANPSPDASQHSSFFIESPKSS
MKTNNPLKLRALKVNFMEGDPSPLLPVLGMYHDPLRNRGSAAAAVAGLECATLLDKAVLS
PESSIYTTASAKTPPRSPEKHTAIAFNFEAGVHQYIDADTDDEGQLLYSVDSSPPKSLPG
STSPKFSTGTRSEKNHFESSPLPTSPKFLRQNCIYSTEALTGKGPSGQEKCKLENHISPD
VRVLPGGGAHGSTRDQSI
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| BDBM50088573 |
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| n/a |
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| Name | BDBM50088573 |
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| Synonyms: | CHEMBL3577208 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H34O10 |
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| Mol. Mass. | 626.6492 |
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| SMILES | COc1cccc(OC)c1C(=O)c1c(O)cc(C)c(OC)c1C1=C(c2c(C1=O)c(OC)c(C)cc2O)c1c(OC)cccc1OC |t:24| |
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| Structure | 
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