| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 3 |
|---|
| Ligand | BDBM50089079 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1497089 (CHEMBL3580222) |
|---|
| IC50 | 23±n/a nM |
|---|
| Citation |  Awadallah, FM; Abou-Seri, SM; Abdulla, MM; Georgey, HH Design and synthesis of potent 1,2,4-trisubstituted imidazolinone derivatives with dual p38aMAPK and ERK1/2 inhibitory activity. Eur J Med Chem94:397-404 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase 3 |
|---|
| Name: | Mitogen-activated protein kinase 3 |
|---|
| Synonyms: | ERK1 | ERK1/ERK2 | Extracellular signal-regulated kinase 1 | Extracellular signal-regulated kinase 1 (ERK1) | MAP kinase ERK1 | MAPK3 | MAPK3/MAPK7 | MK03_HUMAN | Mitogen-activated protein kinase | Mitogen-activated protein kinase 3 | PRKM3 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 43136.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | curated by PDB 4QTB |
|---|
| Residue: | 379 |
|---|
| Sequence: | MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP
|
|
|
|---|
| BDBM50089079 |
|---|
| n/a |
|---|
| Name | BDBM50089079 |
|---|
| Synonyms: | CHEMBL3577639 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H27N3O4 |
|---|
| Mol. Mass. | 517.5745 |
|---|
| SMILES | COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccc(C)cc3)cc2)N=C1c1ccccc1 |c:34| |
|---|
| Structure | 
|
|---|
Search and Browse
