Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHexokinase-4
LigandBDBM50089135
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1495696 (CHEMBL3578684)
EC50 6.0±n/a nM
Citation Park, KLee, BMHyun, KHHan, TLee, DHChoi, HH Design and Synthesis of Acetylenyl Benzamide Derivatives as Novel Glucokinase Activators for the Treatment of T2DM. ACS Med Chem Lett6:296-301 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hexokinase-4
Name:Hexokinase-4
Synonyms:GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:Enzyme
Mol. Mass.:52175.81
Organism:Homo sapiens (Human)
Description:P35557
Residue:465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50089135
n/a
NameBDBM50089135
Synonyms:CHEMBL3577729
TypeSmall organic molecule
Emp. Form.C30H37N5O3
Mol. Mass.515.6465
SMILESCOC[C@H](C)Oc1cc(cc(c1)C(=O)Nc1ccn(C)n1)C#Cc1cccc(NCCN2CCCCC2)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: