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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 10 | ||
| Ligand | BDBM50089223 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1496169 (CHEMBL3578950) | ||
| IC50 | 58±n/a nM | ||
| Citation |  Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors. ACS Med Chem Lett6:413-8 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase 10 | |||
| Name: | Mitogen-activated protein kinase 10 | ||
| Synonyms: | JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 52586.89 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 464 | ||
| Sequence: |
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| BDBM50089223 | |||
| n/a | |||
| Name | BDBM50089223 | ||
| Synonyms: | CHEMBL3577855 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H22N4O2 | ||
| Mol. Mass. | 302.3715 | ||
| SMILES | CC(C)n1c2nc(N[C@H]3CC[C@H](O)CC3)ncc2ccc1=O |r,wU:8.7,wD:11.11,(2.41,-3.7,;1.34,-3.08,;.27,-3.7,;1.33,-1.54,;,-.77,;-1.33,-1.54,;-2.69,-.77,;-4.02,-1.54,;-4.02,-3.09,;-2.68,-3.86,;-2.67,-5.4,;-4.01,-6.17,;-4,-7.41,;-5.35,-5.41,;-5.35,-3.86,;-2.69,.77,;-1.33,1.54,;,.77,;1.33,1.54,;2.67,.77,;2.67,-.77,;3.74,-1.39,)| | ||
| Structure | 
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