Reaction Details |
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Target | Histamine H3 receptor |
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Ligand | BDBM50089372 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1496464 (CHEMBL3578410) |
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Ki | 1.3±n/a nM |
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Citation | Letavic, MA; Aluisio, L; Apodaca, R; Bajpai, M; Barbier, AJ; Bonneville, A; Bonaventure, P; Carruthers, NI; Dugovic, C; Fraser, IC; Kramer, ML; Lord, B; Lovenberg, TW; Li, LY; Ly, KS; Mcallister, H; Mani, NS; Morton, KL; Ndifor, A; Nepomuceno, SD; Pandit, CR; Sands, SB; Shah, CR; Shelton, JE; Snook, SS; Swanson, DM; Xiao, W Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development. ACS Med Chem Lett6:450-4 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H3 receptor |
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Name: | Histamine H3 receptor |
Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 48691.47 |
Organism: | Homo sapiens (Human) |
Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
Residue: | 445 |
Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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BDBM50089372 |
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n/a |
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Name | BDBM50089372 |
Synonyms: | CHEMBL3577956 |
Type | Small organic molecule |
Emp. Form. | C20H29N3O2 |
Mol. Mass. | 343.4632 |
SMILES | O=C(N1CCN(CC1)C1CCC1)c1ccc(CN2CCOCC2)cc1 |
Structure |
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