| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Fyn |
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| Ligand | BDBM50343431 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1497041 (CHEMBL3580016) |
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| Ki | 7500±n/a nM |
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| Citation |  Tintori, C; La Sala, G; Vignaroli, G; Botta, L; Fallacara, AL; Falchi, F; Radi, M; Zamperini, C; Dreassi, E; Dello Iacono, L; Orioli, D; Biamonti, G; Garbelli, M; Lossani, A; Gasparrini, F; Tuccinardi, T; Laurenzana, I; Angelucci, A; Maga, G; Schenone, S; Brullo, C; Musumeci, F; Desogus, A; Crespan, E; Botta, M Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors. J Med Chem58:4590-609 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Fyn |
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| Name: | Tyrosine-protein kinase Fyn |
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| Synonyms: | FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn |
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| Type: | Enzyme |
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| Mol. Mass.: | 60762.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06241 |
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| Residue: | 537 |
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| Sequence: | MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
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| BDBM50343431 |
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| n/a |
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| Name | BDBM50343431 |
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| Synonyms: | 1-(2-Chloro-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-Nphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | CHEMBL1775035 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27ClN6OS |
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| Mol. Mass. | 495.039 |
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| SMILES | ClC(Cn1ncc2c(Nc3ccccc3)nc(SCCN3CCOCC3)nc12)c1ccccc1 |
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| Structure | 
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