Reaction Details |
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Target | Beta-hexosaminidase subunit alpha |
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Ligand | BDBM50089680 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1496352 (CHEMBL3579956) |
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IC50 | 15000±n/a nM |
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Citation | Tropak, MB; Zhang, J; Yonekawa, S; Rigat, BA; Aulakh, VS; Smith, MR; Hwang, HJ; Ciufolini, MA; Mahuran, DJ Pyrimethamine Derivatives: Insight into Binding Mechanism and Improved Enhancement of Mutantß-N-acetylhexosaminidase Activity. J Med Chem58:4483-93 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Beta-hexosaminidase subunit alpha |
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Name: | Beta-hexosaminidase subunit alpha |
Synonyms: | Beta-N-acetylhexosaminidase subunit alpha | Beta-hexosaminidase subunit alpha (HexA) | HEXA | HEXA_HUMAN |
Type: | Protein |
Mol. Mass.: | 60688.46 |
Organism: | Homo sapiens (Human) |
Description: | P06865 |
Residue: | 529 |
Sequence: | MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV
LDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTI
NDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHY
LPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVK
EVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEF
MSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLL
DIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPW
YLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAV
AERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT
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BDBM50089680 |
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n/a |
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Name | BDBM50089680 |
Synonyms: | CHEMBL3577321 |
Type | Small organic molecule |
Emp. Form. | C13H13F3N4 |
Mol. Mass. | 282.2643 |
SMILES | CCc1nc(N)nc(N)c1-c1ccc(cc1)C(F)(F)F |
Structure |
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