Reaction Details |
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Target | Beta-hexosaminidase subunit beta |
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Ligand | BDBM18788 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1496350 (CHEMBL3579954) |
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pH | 4.5±n/a |
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IC50 | 38000±n/a nM |
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Comments | extracted |
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Citation | Tropak, MB; Zhang, J; Yonekawa, S; Rigat, BA; Aulakh, VS; Smith, MR; Hwang, HJ; Ciufolini, MA; Mahuran, DJ Pyrimethamine Derivatives: Insight into Binding Mechanism and Improved Enhancement of Mutantß-N-acetylhexosaminidase Activity. J Med Chem58:4483-93 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Beta-hexosaminidase subunit beta |
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Name: | Beta-hexosaminidase subunit beta |
Synonyms: | Beta-N-acetylhexosaminidase subunit beta | Beta-hexosaminidase subunit beta | Beta-hexosaminidase subunit beta (Hex B) | HEXB | HEXB_HUMAN | Hexosaminidase subunit B |
Type: | Enzyme |
Mol. Mass.: | 63112.58 |
Organism: | Homo sapiens (Human) |
Description: | P07686 |
Residue: | 556 |
Sequence: | MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLP
LSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQA
KTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVY
QDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVD
DQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGK
GQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKC
WESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTI
VEVWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQL
FIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERG
IAAQPLYAGYCNHENM
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BDBM18788 |
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n/a |
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Name | BDBM18788 |
Synonyms: | 6-ethyl-5-phenylpyrimidine-2,4-diamine | CHEMBL22148 | P20 |
Type | Small organic molecule |
Emp. Form. | C12H14N4 |
Mol. Mass. | 214.2664 |
SMILES | CCc1nc(N)nc(N)c1-c1ccccc1 |
Structure |
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