Reaction Details |
| Report a problem with these data |
Target | L-lactate dehydrogenase B chain |
---|
Ligand | BDBM50089927 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1499430 (CHEMBL3583865) |
---|
IC50 | 410±n/a nM |
---|
Citation | Labadie, S; Dragovich, PS; Chen, J; Fauber, BP; Boggs, J; Corson, LB; Ding, CZ; Eigenbrot, C; Ge, H; Ho, Q; Lai, KW; Ma, S; Malek, S; Peterson, D; Purkey, HE; Robarge, K; Salphati, L; Sideris, S; Ultsch, M; VanderPorten, E; Wei, B; Xu, Q; Yen, I; Yue, Q; Zhang, H; Zhang, X; Zhou, A Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett25:75-82 (2015) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
L-lactate dehydrogenase B chain |
---|
Name: | L-lactate dehydrogenase B chain |
Synonyms: | L-lactate dehydrogenase B | L-lactate dehydrogenase B chain | LDH heart subunit | LDH-B | LDH-H | LDHB | LDHB_HUMAN | Lactate dehydrogenase B (LDHB) | Renal carcinoma antigen NY-REN-46 |
Type: | Oxidoreductase; homotetramer |
Mol. Mass.: | 36635.55 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 334 |
Sequence: | MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLK
GEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKF
IIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLG
IHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAY
EVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARG
LTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
|
|
|
BDBM50089927 |
---|
n/a |
---|
Name | BDBM50089927 |
Synonyms: | CHEMBL3581200 |
Type | Small organic molecule |
Emp. Form. | C22H21Cl3O4S |
Mol. Mass. | 487.824 |
SMILES | COc1ccc(Cl)c(SC2=C(O)CC(CC2=O)c2c(Cl)ccc(OC(C)C)c2Cl)c1 |c:9| |
Structure |
|