Reaction Details |
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Target | L-lactate dehydrogenase A chain |
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Ligand | BDBM50089931 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1499429 (CHEMBL3583864) |
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IC50 | 6.0±n/a nM |
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Citation | Labadie, S; Dragovich, PS; Chen, J; Fauber, BP; Boggs, J; Corson, LB; Ding, CZ; Eigenbrot, C; Ge, H; Ho, Q; Lai, KW; Ma, S; Malek, S; Peterson, D; Purkey, HE; Robarge, K; Salphati, L; Sideris, S; Ultsch, M; VanderPorten, E; Wei, B; Xu, Q; Yen, I; Yue, Q; Zhang, H; Zhang, X; Zhou, A Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett25:75-82 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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L-lactate dehydrogenase A chain |
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Name: | L-lactate dehydrogenase A chain |
Synonyms: | Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59 |
Type: | Protein |
Mol. Mass.: | 36694.85 |
Organism: | Homo sapiens (Human) |
Description: | P00338::PDB Code: 4ajp |
Residue: | 332 |
Sequence: | MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
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BDBM50089931 |
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n/a |
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Name | BDBM50089931 |
Synonyms: | CHEMBL3581197 |
Type | Small organic molecule |
Emp. Form. | C28H23Cl3O4S |
Mol. Mass. | 561.904 |
SMILES | C[C@@H](OC(=O)Cc1ccc(Cl)c(SC2=C(O)CC(CC2=O)c2c(Cl)cccc2Cl)c1)c1ccccc1 |r,c:13| |
Structure |
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