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TargetL-lactate dehydrogenase A chain
LigandBDBM50089950
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1499429 (CHEMBL3583864)
IC50 170±n/a nM
Citation Labadie, SDragovich, PSChen, JFauber, BPBoggs, JCorson, LBDing, CZEigenbrot, CGe, HHo, QLai, KWMa, SMalek, SPeterson, DPurkey, HERobarge, KSalphati, LSideris, SUltsch, MVanderPorten, EWei, BXu, QYen, IYue, QZhang, HZhang, XZhou, A Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett25:75-82 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
L-lactate dehydrogenase A chain
Name:L-lactate dehydrogenase A chain
Synonyms:Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59
Type:Protein
Mol. Mass.:36694.85
Organism:Homo sapiens (Human)
Description:P00338::PDB Code: 4ajp
Residue:332
Sequence:
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50089950
n/a
NameBDBM50089950
Synonyms:CHEMBL3581178
TypeSmall organic molecule
Emp. Form.C22H21Cl3N2O2S
Mol. Mass.483.838
SMILESOC1=C(Sc2ccccc2Cl)C(=O)CC(C1)c1c(Cl)ccc(N2CCNCC2)c1Cl |c:1|
Structure
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