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TargetBeta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
LigandBDBM50090510
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1498284
IC50>30000±n/a nM
Citation Sato KTakahagi HYoshikawa TMorimoto STakai THidaka KKamaura MKubo OAdachi RIshii TMaki TMochida TTakekawa SNakakariya MAmano NKitazaki T Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase-2 Inhibitors. J Med Chem 58:3892-909 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Name:Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Synonyms:GGNT3 | GNT-III | GlcNAc-T III | MGAT3 | N-acetylglucosaminyltransferase III | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III
Type:PROTEIN
Mol. Mass.:61324.81
Organism:Homo sapiens (Human)
Description:ChEMBL_107586
Residue:533
Sequence:
MKMRRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPNLVSSFFWNNAPVTPQA
SPEPGGPDLLRTPLYSHSPLLQPLPPSKAAEELHRVDLVLPEDTTEYFVRTKAGGVCFKP
GTKMLERPPPGRPEEKPEGANGSSARRPPRYLLSARERTGGRGARRKWVECVCLPGWHGP
SCGVPTVVQYSNLPTKERLVPREVPRRVINAINVNHEFDLLDVRFHELGDVVDAFVVCES
NFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDHFPPGGRQDGWIADDYLRTFLTQDG
VSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYDGWTEPFAFHMRKSLYGFFWKQPGTLE
VVSGCTVDMLQAVYGLDGIRLRRRQYYTMPNFRQYENRTGHILVQWSLGSPLHFAGWHCS
WCFTPEGIYFKLVSAQNGDFPRWGDYEDKRDLNYIRGLIRTGGWFDGTQQEYPPADPSEH
MYAPKYLLKNYDRFHYLLDNPYQEPRSTAAGGWRHRGPEGRPPARGKLDEAEV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50090510
n/a
NameBDBM50090510
Synonyms:CHEMBL3581716
TypeSmall organic molecule
Emp. Form.C24H23F2N3O3S
Mol. Mass.471.52
SMILESCC(=O)Nc1cc(cc2CCN(CCc3ccccc3)c12)S(=O)(=O)Nc1ccc(F)cc1F
Structure
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