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TargetSerine/threonine-protein kinase Chk1
LigandBDBM50091291
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1500168 (CHEMBL3584717)
IC50 4.2±n/a nM
Citation Gazzard, LWilliams, KChen, HAxford, LBlackwood, EBurton, BChapman, KCrackett, PDrobnick, JEllwood, CEpler, JFlagella, MGancia, EGill, MGoodacre, SHalladay, JHewitt, JHunt, HKintz, SLyssikatos, JMacleod, CMajor, SMédard, GNarukulla, RRamiscal, JSchmidt, SSeward, EWiesmann, CWu, PYee, SYen, IMalek, S Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1. J Med Chem58:5053-74 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase Chk1
Name:Serine/threonine-protein kinase Chk1
Synonyms:CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:Enzyme Catalytic Domain
Mol. Mass.:54443.02
Organism:Homo sapiens (Human)
Description:gi_166295192
Residue:476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50091291
n/a
NameBDBM50091291
Synonyms:CHEMBL3582203
TypeSmall organic molecule
Emp. Form.C25H25N5
Mol. Mass.395.4995
SMILESC[C@H]1C[C@@H](C)CN(Cc2ccc(cc2)-c2cnc3[nH]c4cnc(cc4c3c2)C#N)C1 |r|
Structure
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