| Reaction Details |
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 | Report a problem with these data |
| Target | Somatostatin receptor type 3 |
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| Ligand | BDBM50091414 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1498170 (CHEMBL3583390) |
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| IC50 | 0.600000±n/a nM |
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| Citation |  Shah, SK; He, S; Guo, L; Truong, Q; Qi, H; Du, W; Lai, Z; Liu, J; Jian, T; Hong, Q; Dobbelaar, P; Ye, Z; Sherer, E; Feng, Z; Yu, Y; Wong, F; Samuel, K; Madiera, M; Karanam, BV; Reddy, VB; Mitelman, S; Tong, SX; Chicchi, GG; Tsao, KL; Trusca, D; Feng, Y; Wu, M; Shao, Q; Trujillo, ME; Eiermann, GJ; Li, C; Pachanski, M; Fernandez, G; Nelson, D; Bunting, P; Morissette, P; Volksdorf, S; Kerr, J; Zhang, BB; Howard, AD; Zhou, YP; Pasternak, A; Nargund, RP; Hagmann, WK Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes. ACS Med Chem Lett6:513-7 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Somatostatin receptor type 3 |
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| Name: | Somatostatin receptor type 3 |
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| Synonyms: | SOMATOSTATIN SST3 | SSR3_RAT | Somatostatin receptor | Somatostatin receptor 3 | Somatostatin receptor type 3 | Sstr3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 47161.54 |
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| Organism: | RAT |
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| Description: | SOMATOSTATIN SST3 SSTR3 RAT::P30936 |
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| Residue: | 428 |
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| Sequence: | MAAVTYPSSVPTTLDPGNASSAWPLDTSLGNASAGTSLAGLAVSGILISLVYLVVCVVGL
LGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLV
MAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARMVSAAVWVASAVVVLPVV
VFSGVPRGMSTCHMQWPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLLIVVKVRSTTRR
VRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPEEPAF
FGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRVRSQEPGSGPPEKTEEE
EDEEEEERREEEERRMQRGQEMNGRLSQIAQPGPSGQQQRPCTGTAKEQQLLPQEATAGD
KASTLSHL
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| BDBM50091414 |
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| n/a |
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| Name | BDBM50091414 |
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| Synonyms: | CHEMBL3582336 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H24FN9O2 |
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| Mol. Mass. | 525.537 |
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| SMILES | CCn1cc(cn1)[C@]1(N[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccc(F)cn1)c1nn(C)c(=O)o1 |r| |
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| Structure | 
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