| Reaction Details |
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 | Report a problem with these data |
| Target | Monocarboxylate transporter 1 |
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| Ligand | BDBM50092077 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1498543 (CHEMBL3584796) |
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| IC50 | 400±n/a nM |
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| Citation |  Gurrapu, S; Jonnalagadda, SK; Alam, MA; Nelson, GL; Sneve, MG; Drewes, LR; Mereddy, VR Monocarboxylate transporter 1 inhibitors as potential anticancer agents. ACS Med Chem Lett6:558-61 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monocarboxylate transporter 1 |
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| Name: | Monocarboxylate transporter 1 |
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| Synonyms: | MCT 1 | MOT1_RAT | Mct1 | Monocarboxylate transporter 1 | Monocarboxylate transporter 1 (MCT1) | Slc16a1 | Solute carrier family 16 member 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 53245.17 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P53987 |
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| Residue: | 494 |
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| Sequence: | MPPAIGGPVGYTPPDGGWGWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSW
ISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIGVIG
GLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLI
LGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKESLQEAGKSDANTDLIGGSPKGEKLSVFQ
TVNKFLDLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAF
VDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAF
GWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACG
VILIIAGLYLFIGMGINYRLVAKEQKAEEKKRDGKEDETSTDVDEKPKKTMKETQSPAPL
QNSSGDPAEEESPV
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| BDBM50092077 |
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| n/a |
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| Name | BDBM50092077 |
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| Synonyms: | CHEMBL3582414 | US9296728, 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12N2O2 |
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| Mol. Mass. | 264.2787 |
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| SMILES | OC(=O)C(=C\c1ccc(cc1)N(CC#C)CC#C)\C#N |
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| Structure | 
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