Reaction Details |
| Report a problem with these data |
Target | Steroid 17-alpha-hydroxylase/17,20 lyase |
---|
Ligand | BDBM50092142 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1498855 (CHEMBL3583829) |
---|
IC50 | >10000±n/a nM |
---|
Citation | Hoyt, SB; Park, MK; London, C; Xiong, Y; Tata, J; Bennett, DJ; Cooke, A; Cai, J; Carswell, E; Robinson, J; MacLean, J; Brown, L; Belshaw, S; Clarkson, TR; Liu, K; Liang, GB; Struthers, M; Cully, D; Wisniewski, T; Ren, N; Bopp, C; Sok, A; Cai, TQ; Stribling, S; Pai, LY; Ma, X; Metzger, J; Verras, A; McMasters, D; Chen, Q; Tung, E; Tang, W; Salituro, G; Buist, N; Kuethe, J; Rivera, N; Clemas, J; Zhou, G; Gibson, J; Maxwell, CA; Lassman, M; McLaughlin, T; Castro-Perez, J; Szeto, D; Forrest, G; Hajdu, R; Rosenbach, M; Ali, A Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys. ACS Med Chem Lett6:573-8 (2015) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Steroid 17-alpha-hydroxylase/17,20 lyase |
---|
Name: | Steroid 17-alpha-hydroxylase/17,20 lyase |
Synonyms: | CP17A_HUMAN | CYP17 | CYP17A1 | CYPXVII | Cytochrome P450 17A1 | Cytochrome P450 C17 (CYP17 ) | Cytochrome P450 C17 (CYP17) | Cytochrome P450 CYP17 | Cytochrome P450-C17 | Cytochrome P450-C17 (CYP17) | P450-C17 | S17AH | Steroid 17-alpha-Monooxygenase (CYP17) | Steroid 17-alpha-hydroxylase/17,20 lyase | Steroid 17-alpha-monooxygenase | cytochrome P450 monooxygenase 17 alpha hydroxylase/17,20-lyase (CYP17) |
Type: | Enzyme |
Mol. Mass.: | 57382.42 |
Organism: | Homo sapiens (Human) |
Description: | E.coli expressing human CYP17 |
Residue: | 508 |
Sequence: | MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH
WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS
LICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN
DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF
GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV
LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP
AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP
KVVFLIDSFKVKIKVRQAWREAQAEGST
|
|
|
BDBM50092142 |
---|
n/a |
---|
Name | BDBM50092142 |
Synonyms: | CHEMBL3582477 |
Type | Small organic molecule |
Emp. Form. | C18H17F2N3O |
Mol. Mass. | 329.3439 |
SMILES | CC(C)(O)c1cncc(c1)-c1nc2cc(F)c(F)cc2n1C1CC1 |
Structure |
|