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TargetCytochrome P450 11B2, mitochondrial
LigandBDBM50092185
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1498857 (CHEMBL3583831)
IC50 0.400000±n/a nM
Citation Hoyt, SBPark, MKLondon, CXiong, YTata, JBennett, DJCooke, ACai, JCarswell, ERobinson, JMacLean, JBrown, LBelshaw, SClarkson, TRLiu, KLiang, GBStruthers, MCully, DWisniewski, TRen, NBopp, CSok, ACai, TQStribling, SPai, LYMa, XMetzger, JVerras, AMcMasters, DChen, QTung, ETang, WSalituro, GBuist, NKuethe, JRivera, NClemas, JZhou, GGibson, JMaxwell, CALassman, MMcLaughlin, TCastro-Perez, JSzeto, DForrest, GHajdu, RRosenbach, MAli, A Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys. ACS Med Chem Lett6:573-8 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 11B2, mitochondrial
Name:Cytochrome P450 11B2, mitochondrial
Synonyms:Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase
Type:Protein
Mol. Mass.:57582.15
Organism:Homo sapiens (Human)
Description:P19099
Residue:503
Sequence:
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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BDBM50092185
n/a
NameBDBM50092185
Synonyms:CHEMBL3582474
TypeSmall organic molecule
Emp. Form.C16H13F2N3O
Mol. Mass.301.2907
SMILESCOc1cncc(c1)-c1nc2cc(F)c(F)cc2n1C1CC1
Structure
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